Alex Noren will aim to defend the Nedbank Golf Challenge hosted by Gary Player title in the company of Race to Dubai Rankings leader Tommy Fleetwood and Rafa Cabrera Bello when play starts on Thursday.
The Swede already possesses one of this season's Rolex Series title thanks to his win at the BMW PGA Championship and will hope to emulate his performance in Sun City from last year in an attempt to win a second.
Noren, who finished six shots clear at Gary Player CC 12 months ago, will tee off at 11.01 alongside Aberdeen Asset Management Scottish Open winner Cabrera Bello and Fleetwood, who leads the Rankings by 134,838 points.
Italian Open champion Tyrrell Hatton is off at 10.28 with two-time Major Champion Martin Kaymer and the 2018 European Ryder Cup Captain Thomas Bjørn.
Home favourite Louis Oosthuizen starts at 10.50 alongside Ross Fisher and Francesco Molinari, who are currently sixth and ninth in the Rankings respectively.
The trio of Matt Fitzpatrick, Bernd Wiesberger and Paul Dunne have all won on tour this season and will be going for their second titles when they tee off at 10.39.
Padraig Harrington arrives in South Africa on the back of a fourth placed finish in Turkey and will hope to claim his first victory of the season alongside Charl Schwartzel and Lee Westwood.
Ian Poulter, Graeme Storm and Johannesburg native Dylan Frittelli will get play under way at 09.00 from the first tee.