“I hit it perfect, I only missed two shots from the tee,” said Gonzalez. “Then I hit fairways, hit greens, made some good putts and that’s why I shot 65.
“I tried to relax the last two or three weeks but I played with little tension. On Tuesday’s practice I said ‘come on, relax’ and it worked.
“I’m feeling very good and we’ll see what happens over the next three days.”
Kieffer had a 25 foot putt for the outright lead at the last, but had to settle for a par to conclude his eight birdie, one bogey round.
It continued an impressive rookie European Tour campaign for the 23 year old, who currently sits 77th in The Race to Dubai and could force his way into the top 60 and Dubai World Championship with a good finish this week.
Colsaerts was not the only one of the leaders to have been laid low recently, with Kieffer also suffering the effects of a cold in the tournament build-up.
He said: “I’m very happy, 65 is a very good score. I didn’t feel so good coming here because I wasn’t hitting it that well the last few weeks and I’ve had a cold.
“I wasn’t really expecting a lot and I just took it shot for shot. Mentally it’s nice to shoot a good score, you always feel better when you’re playing well and have a good score so hopefully I’ll have another three good rounds.”
Australian Marcus Fraser was a shot behind in fourth after a 66, with England’s Steve Webster on five under.
Local favourite Francesco Molinari made a good start with a 68, while another Italian star – Matteo Manassero – was among the afternoon starters.