The American stormed to an utterly dominant seven shot victory at Emirates Golf Club in 2019 to claim his first European Tour title and add to his growing list of career achievements.
He has won the US Amateur and professionally on both sides of the Atlantic but has yet to make a splash in golf's four biggest events.
His best finish in 14 Majors has been a tie for 15th at the 2016 U.S. Open Championship but he is determined to improve on that record this summer.
"All of my mind is taken up for the need to do well in the Majors," he said. "That's what I haven't done well in particularly in my career so far and I am keen on changing that.
"It's (scheduling) very, very important. It's one that's difficult to handle and at the same time, we're trying our best with what fits well with my type of game and my style of game.
"Just trying to fit the golf courses that work for me best, and sometimes you're not going to be able to play all of them, but I need time to rest and time to get ready and we take that all into consideration. We may not get it right but hopefully we do."
Emirates Golf Club may present a different challenge this year both due to the course and DeChambeau himself.
All of my mind is taken up for the need to do well in the Majors
The 26-year-old has bulked up and added some distance off the tee, while the rough this year is up from 2019, and DeChambeau is excited by the challenge.
"I'm honoured to be back," he said. "I love this city. I think it's an incredible place and desert golf has always suited my style of play.
"The golf course is in immaculate shape. The greens are perfect. The rough is longer this year, which is pretty interesting and I also just love hitting it off the fairways out here. It's a lot of great fun and a lot of scoring opportunities.
"For me it's a great test of golf and I had a lot of fun last year. Let's hopefully do it again.
"It's going to take great ball striking, iron play, and making a lot of putts.
"My wedge game is much improved I feel and personally I'm looking forward to the new test this week. The rough is a little bit longer so being in the fairway is going to be key and if you have a great wedge game, you can get up and down and fix those mistakes you have.
"It's definitely a viable option to win."