With the chasing pack unable to reel him in over Le Golf National’s notoriously tough back nine, eight straight pars kept Wiesberger in control before he finished things in style with a birdie from 15 feet on the last.
That gave him a closing round of 65, a 13 under total and a three shot winning margin over James Morrison.
It also provided a first visit to the winner’s circle since capturing two titles in 2012, and with a €500,000 cheque for first place the biggest pay day of his European Tour career.
The victory caps a sparkling run of form during which Wiesberger finished sixth, third, fourth and second in his first four events of the season, before adding another runner-up finish in Ireland.
“It's been a great first half of the year for me so far,” he said. “I've had a lot of great success but just couldn't pull it quite off. To stand here with the trophy right now, it's pretty sweet.
“I just hit a great shot down the fourth before the horns were blowing and they took us off the course. I liked my yardage, and had a good shot in there and had some momentum building, chipped in, holed a long putt.
“I felt really comfortable out there. I had a great weekend, only one bogey, and 66, 65 - that's not a bad score.” Bernd Wiesberger
“This tournament is very special to me. It’s one of the biggest events we have on Tour every year and probably the most tradition, the oldest one on Continental Europe.
“I’m very proud to be on the winner's list now, on this trophy dating back to 1906 it says here. It's amazing and it was a great week. I really enjoyed playing in front of these crowds here and performing the way I did.
“I have to say, James Morrison who I played with played great golf, as well, and gave me a good run which made it quite tight at the end.”
Van Zyl and Rafa Cabrera-Bello claimed the other spots after finishing third and fifth respectively, with Kaymer sandwiched between the pair on seven under after finding water on the last and running up a double bogey.
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