Knox won last year's event at Ballyliffin Golf Club with a dramatic play-off victory and this time he has been grouped with England's Fleetwood and home hope Lowry, who won the event as an amateur in 2009 and claimed victory at the first Rolex Series event of the year at January's Abu Dhabi HSBC Championship Presented by EGA.
Race to Dubai Rankings Presented by Rolex leader Matt Wallace tees off at 13:20 alongside 2017 Irish Open winner Jon Rahm and five-time European Tour winner Louis Oosthuizen.
Graeme McDowell, two weeks before playing the Open Championship on his home course of Royal Portrush, will start his Irish Open challenge at 08:30 alongside fellow Ryder Cup winners Martin Kaymer and Thorbjørn Olesen.
Ireland's Padraig Harrington, the 2007 winner of the Irish Open, begins his first round at 13:10 alongside English duo Ian Poulter and Tyrrell Hatton in a grouping that boasts a combined 30 European Tour victories.
Christian Bezuidenhout, fresh from his win at Real Club Valderrama last week, starts at 13:45 alongside Italian duo Andrea Pavan and Guido Migliozzi.
The full draw can be viewed here.
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