Syme's three-over total, after a level-par 70 to close, was enough for a share of 42nd place at The Renaissance Club, where American Xander Schauffele won his first Rolex Series title.
Syme, who will celebrate his 27th birthday the day after picking up his prize, follows in the footsteps of Richie Ramsay who won the inaugural award last year.
"It’s a real honour to win the Jock MacVicar Memorial Award," said Syme, who is from Kirkcaldy. "The Genesis Scottish Open is special week for us Scots, and this award adds something extra.
"Jock was such a big supporter of Scottish golf and it’s fitting to see his name on this award. Thanks to Martin Dempster for presenting me with the award and the AGW and the DP World Tour for giving the Scottish players the chance to compete for it every year."
Association of Golf Writers (AGW) president MacVicar passed away in April 2021 at the age of 83.
The trophy was commissioned by the DP World Tour on the AGW’s behalf to commemorate the man known fondly by friends and colleagues as ‘The Doyen’.
Dempster, AGW chairman, said: "We are delighted to see Connor becoming the second winner of the Jock MacVicar Memorial Award.
"As was the case with lots of players over the years, Jock covered Connor's career when he was an amateur and was pleased to see him quickly progress to the DP World Tour after turning professional.
"As is the case with all the other Scottish players on the DP World Tour, Connor is always happy to speak to the press after a round. He joins Richie Ramsay in becoming a worthy winner of this award, which was kindly donated by the DP World Tour on our behalf."